The second session "Early Life Exposures - Long-term Health Consequences: Session 2, Metals and Metal Mixtures" features SRP grantees Dr. Robert Wright (Harvard University) and Dr. Rebecca Fry (UNC-CH) and their work with early exposure to metals and the resulting developmental effects. To better understand the neurodevelopmental consequences of exposure to mixtures of lead, manganese, and arsenic, Dr. Wright is conducting three cohort studies of metals and neurodevelopment among populations of children in Bangladesh, Mexico and Oklahoma. The combined efforts of these studies investigate the effects of mixed metal exposures on child development, comparing different developmental windows of exposure from prenatal life to age two.
For general information contact Justin Crane
by telephone at 919 794-4702
Prenatal exposure to cadmium has been associated with poor birth outcomes including low birth weight. Dr. Fry's research aims to obtain a better understanding of the underlying biological mechanisms involved in this association. This study employs in vitro and in vivo approaches to investigate gene-environment interactions that influence cadmium-induced signaling of inflammatory response genes.
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